MESNA HAS ANTIOXIDANT POTENTIAL ON INTESTINE REMOTE ORGAN INJURY INDUCED BY INTESTINAL ISCHEMIA/ REPERFUSION

An ischemia-reperfusion (I/R) injury of small intestine is a serious and common condition that result the blockage superior mesenteric artery (SMA) because significant clinical problems. This study evaluated effect Mesna on systemic induced by ischemia/reperfusion (IR) in also liver, kidney lung as remote organs. Forty Wistar albino rats were randomly divided into four groups: control, ischemia, IR Mesna. Ischemia period was executed clamping for 2 h then reperfusion permitted removing clamp from SMA h. Activities antioxidant enzymes levels measured all tissue samples. Microscopic examination performed light electron microscope. Oxidative damage determined ischemia (p